Fig. 4: Post-vaccination anti-VACV responses. | npj Vaccines

Fig. 4: Post-vaccination anti-VACV responses.

From: The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates

Fig. 4

a Reciprocal PRNT50 (neutralising antibody) titres against VACV (Western Reserve) for each NHP at the indicated times after a single vaccination with 107 pfu of SCV-ZIKA/CHIK, with mean ± SEM titres shown far right. Limit of detection one in ten serum dilution. b Reciprocal endpoint ELISA anti-VACV (Western Reserve) antibody titres for each NHP at the indicated times after a single vaccination with 107 pfu of SCV-ZIKA/CHIK, with mean ± SEM titres shown far right. Limit of detection 1 in 100 serum dilution. c Reciprocal PRNT50 titres as for a after two vaccinations with 108 pfu of SCV-ZIKA/CHIK. d Reciprocal endpoint ELISA titres as for b after two vaccinations with 108 pfu of SCV-ZIKA/CHIK. e Reciprocal PRNT50 titres as for a after two vaccinations with 108 pfu of SCV-control. f Reciprocal endpoint ELISA titres as for b after two vaccinations with 108 fu of SCV-control (no antibody responses to VACV were detected in NHPs 5547 and 5554 that received the inactivated ZIKV vaccine).

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