Fig. 1: G100–ZVex combination eradicates established tumors. | npj Vaccines

Fig. 1: G100–ZVex combination eradicates established tumors.

From: Intratumoral immune activation with TLR4 agonist synergizes with effector T cells to eradicate established murine tumors

Fig. 1

a Schematic of tumor inoculation, ZVex immunization, and G100 administration. Female C57BL/6 mice (n = 18/group) were inoculated with B16/OVA cells (flank, subcutaneously) on day 0. Once tumors became palpable (averaged 5 mm in diameter), mice were immunized once with ZVex/OVA and given intratumoral G100 that was continued twice weekly until observation of complete tumor regression or euthanized due to tumor burden. b Tumor size and c survival were monitored and recorded at least 2–3 times weekly. d In a bilateral B16/OVA model, tumor inoculation of the treated tumor and its treatment regimen were the same as described in (a) (n = 9/group). Inoculation of the vehicle-treated tumors occurred on day 7. Tumor sizes were plotted as average tumor volume ± SEM. Death was recorded as a result of death defined by euthanasia criteria. Data are representative of at least three independent experiments (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).

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