Fig. 1: Immunization of rhesus macaques with HIV-1 Env recombinant protein adjuvanted with ALFQ or HIV-1 Env-encoding mRNA-LNP elicits comparable titers of gp120-specific serum IgG. | npj Vaccines

Fig. 1: Immunization of rhesus macaques with HIV-1 Env recombinant protein adjuvanted with ALFQ or HIV-1 Env-encoding mRNA-LNP elicits comparable titers of gp120-specific serum IgG.

From: Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

Fig. 1

a Rhesus macaque vaccine regimen and biospecimen collection schedule. The different immunogens are listed on the right side. b Serum IgG binding titers for each group are shown as mean log area-under-the-curve (AUC) against A244 gp120, A244 gp120 mutants, and B.63521 gp120. A244 gp120 was mutated at the ADCC site of immune pressure observed in the RV144 trial (A244 K169V). In addition, the V3-glycan (N295A/N301A/N332A), V2-glycan (N156K/N160K), CD4 binding site (delta371I/P363N) neutralizing epitopes were mutated on A244 gp120. The group mean and standard error are shown (n = 5 per group). Arrows indicate immunization timepoints.

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