Fig. 7: Model of action.
From: Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection
After poxvirus infection in the peritoneal cavity, two distinct subtypes of neutrophil (Nα and Nβ) are generated. Nβ are characterized by overexpression of the trans-endothelial migration marker VLA-4 and an increased ability to interact with antigen-specific CD8+ T cells in the spleen (top panel). Poxvirus infection in combination with VLA-4 inhibition increases Nβ/Nα ratio in peritoneal cavity and spleen leading to augmented HIV-specific CD8 T-cell responses (bottom panel).
