Fig. 2: Infectivity and immunogenicity of T-LAIV in ferrets. | npj Vaccines

Fig. 2: Infectivity and immunogenicity of T-LAIV in ferrets.

From: Intranasal powder live attenuated influenza vaccine is thermostable, immunogenic, and protective against homologous challenge in ferrets

Fig. 2

a Vaccine virus detected in ferret nasal washes post-vaccination. Virus titer was determined by titration in embryonated chicken eggs. Kruskal–Wallis test with a post hoc Dunn’s multiple comparisons test. Error bars indicate mean ± 95% CI. n = 4–6. b Mucosal antibody response detected in ferret nasal washes post-vaccination. Nasal mucosa immunoglobulin response detected in ferret nasal washes by ELISA (32 dpv). Kruskal–Wallis test with post hoc Dunn’s multiple comparisons test. Error bars indicate geometric mean ± 95% CI. n = 4–6. c Seroconversion of ferrets following vaccination with LAIV, thermostable LAIV (T-LAIV), T-LAIV + adjuvant, or PBS. Serum hemagglutinin antibody titers pre-vaccination, post-vaccination, and post-challenge were determined by hemagglutinin-inhibition assay. Error bars indicate geometric mean ± 95% CI. n = 4–6.

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