Fig. 8: Type-specific neutralizing antibody responses of representative animals in each PIV primed/LAV boosted group.

Sera were depleted of antibody by sequential rounds of incubation with polystyrene magnetic particles coated with BSA (control depleted), DENV-2 virions (D2 depleted), or DENV-1, -3, and -4 virions (D1 + D3 + D4 depleted). Neutralizing activity of depleted sera was tested by FlowNT. Data are presented as log10-transformed NT50 values against each DENV type.