Fig. 6: The germline usage of gHgL and pentamer-specific antibodies. | npj Vaccines

Fig. 6: The germline usage of gHgL and pentamer-specific antibodies.

From: A conditionally replication-defective cytomegalovirus vaccine elicits potent and diverse functional monoclonal antibodies in a phase I clinical trial

Fig. 6

a Heavy chain variable region germline gene distribution of gHgL mAbs in the six subjects (black bars), compared to the naive variable region gene repertoire (red bars). b The kappa chain variable region germline gene distribution of gHgL mAbs in the six subjects (black bars), compared with the naive variable region gene repertoire (red bars). c Heatmap frequency of V-gene usage of the paired gHgL antibodies. d The pie chart of antibody variable region gene germline distribution in each subject for the gHgL antibodies. Red color indicates the HV1-18 germline, and the KV1-5 germline. The numbers of antibodies of each subject are shown in the middle of the pie. The percentage of HV1-18, and KV1-5 germline are indicated. e Heavy chain variable region gene germline distribution of the pentamer-specific mAbs in the six subjects (black bars), compared to the naive variable region gene repertoire (red bars). f Heatmap frequency of V-gene usage of the paired antibodies to pentamer. g The light-chain pairing preference of mAbs to different HCMV antigens. The reference naive antibody variable region gene repertoire is from a previous study36.

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