Fig. 3: HA clamp provides protection from influenza A virus infection in ferrets.
From: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
A Schematic outlining the vaccination and dose schedule for the H1 ferret study. B Weight loss curves, C titres of infectious virus recovered from daily nasal washes, D peak viral titre in nasal wash samples and E titres of neutralising antibody in the serum of vaccinated ferrets prior to virus challenge. F Schematic outlining the vaccination and dose schedule for the H3 ferret study. G Weight loss curves, H titres of infectious virus recovered from daily nasal washes, I peak nasal wash viral titre and J titres of neutralising antibody in the serum of vaccinated ferrets prior to virus challenge. Bars represent the geometric mean with error bars representing SD while circles show results for individual animals. For virus neutralisation and peak viral titre graphs: ***p < 0.0005, ****p < 0.0001, determined using one-way ANOVA with Tukey’s multiple comparison post hoc test. For nasal wash viral titre graphs: *p < 0.05, **p < 0.005 compared to PBS-immunised animals on the corresponding sampling day, as measured by repeated measures two-way ANOVA with Dunnet’s test for multiple comparisons.
