Fig. 5: Vaccination with H1 IZP or H1 clamp induces NA and stem-specific antibodies, respectively. | npj Vaccines

Fig. 5: Vaccination with H1 IZP or H1 clamp induces NA and stem-specific antibodies, respectively.

From: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses

Fig. 5

Serum from ferrets vaccinated with 2 doses of either PBS, H1 clamp adjuvanted with either Alum or SWE, or H1 IZP adjuvanted with SWE was collected 4 weeks after the second dose and assessed for binding to A neuraminidase (NA) from a H1N1pdm09 virus, B NA from a H5N1 virus and C the stem domain of H1 HA. Data is representative of geometric mean with error bars representing the SD. ***p < 0.0005, ****p < 0.0001, determined using one-way ANOVA with Tukey’s multiple comparison post hoc test.

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