Fig. 2: anti-Pfs230 induces superior functional activity than anti-Pfs25 after two immunizations. | npj Vaccines

Fig. 2: anti-Pfs230 induces superior functional activity than anti-Pfs25 after two immunizations.

From: Malaria transmission-blocking conjugate vaccine in ALFQ adjuvant induces durable functional immune responses in rhesus macaques

Fig. 2

a transmission reducing activity, by group, 2 weeks (d84) and 14 weeks (d168) after dose 2. Each data point represents TRA from one monkey; red lines denote arithmetic mean TRA. b Nonlinear 4-parameter curve fit of log (EU) vs TRA. Antibody levels shown account for dilution of immune monkey sera in the feeding assay. An IC50 was estimated for both antigens using a 4-parameter curve fit of the log(titer) vs %TRA for each monkey of the d84 and d168 SMFA data combined. Correlation analysis of ELISA vs TRA showed strong correlation for both antigens. Pfs230D1: Spearman r = 0.92, p < 0.0001; Pfs25: Spearman r = 0.94, p < 0.0001.

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