Fig. 6: IgG subclass distribution in the immune sera. | npj Vaccines

Fig. 6: IgG subclass distribution in the immune sera.

From: Malaria transmission-blocking conjugate vaccine in ALFQ adjuvant induces durable functional immune responses in rhesus macaques

Fig. 6

IgG subclasses (IgG1+3, IgG1, IgG2, IgG4) and IgM antibody levels in sera from Rhesus vaccinated with high dose (a) and low dose (b) of the Pfs230D1-EPA conjugate formulated with ALFQ assayed at different time points (days 0, 84, 350 and 600) during the study. Error bars represent the mean and standard deviation. Correlation between the functional activity (%TRA) of sera from day 600 and levels of IgG subclasses IgG2 (c), IgG1 (d) and IgG1+3 (e). Immune sera from each animal were analyzed by ELISA using the Rhesus specific monoclonal antibody isotype controls listed in Supplementary Table 5.

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