Fig. 6: Antibodies from vaccinated sheep bind P. falciparum sporozoites and inhibit traversal through hepatocytes. | npj Vaccines

Fig. 6: Antibodies from vaccinated sheep bind P. falciparum sporozoites and inhibit traversal through hepatocytes.

From: Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites

Fig. 6

a HC-04 cell traversal by sporozoites in the presence of antibodies from sheep vaccinated with empty BP, B-cell epitope-coated BPs and B/T-cell epitope-coated BPs, respectively. b HC-04 cell traversal by sporozoites in the presence naïve mouse IgG (mIgG) or monoclonal anti-NANP3 (clone 2A10) served as negative and positive control, respectively. For gating strategy see Supplementary Material Fig. 1. Data shown are pooled from three independent experiments relative to the no sporozoites control. p < 0.01 using Wilcoxon test. ** indicates statistical significance from empty BPs. *** indicates statistical significance from the mouse IgG negative control. All antibodies were used at 10 μg/ml. All data are mean and error bars represent +/–SD.

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