Fig. 3: Relationship of age, frailty status, and BMI to pre-vaccination hemagglutination antibody inhibition (HAI) titers. | npj Vaccines

Fig. 3: Relationship of age, frailty status, and BMI to pre-vaccination hemagglutination antibody inhibition (HAI) titers.

From: Sex-specific effects of aging on humoral immune responses to repeated influenza vaccination in older adults

Fig. 3

Estimates for the relationship of age in decades (Age/10), frailty status, and BMI (five-unit intervals, BMI/5) to pre-vaccination HAI titers were derived from multilevel mixed-effects models controlling for study year for H1N1 (a), H3N2 (b), and influenza B (c). Expanded age models controlling for frailty and BMI are shown for responses to H1N1 (d), H3N2 (e), and influenza B (f). Expanded models for responses to H1N1 (g), H3N2 (h), and influenza B (i) were then amended to include cubic B-splines for age with knots at 5-year intervals. Models for the whole study population adjusted for sex, while sex-specific estimates included an interaction term allowing effects to differ by sex and are shown with 95% confidence intervals. Asterisks indicate significant sex differences.

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