Fig. 3: Splenic T cell responses in mice vaccinated with SpFN vaccine. | npj Vaccines

Fig. 3: Splenic T cell responses in mice vaccinated with SpFN vaccine.

From: SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses

Fig. 3

a–c Flow cytometry-based characterization of mouse splenocytes at days 5 and 10 post-vaccination measuring SARS-CoV-2 spike-specific intracellular cytokine responses in CD4+ and CD8+ T cells a IL-2-, b IFN-γ- c TNF-α-, and d IL-4- secreting T cells. Dots represent data from individual vaccinated or naïve mice (n = 5/group). Bars represent mean + s.d. Statistical significance between the groups was determined using a nonparametric Mann–Whitney U-test with p ≤ 0.05 considered as statistically significant. The gating strategy applied for the evaluation of flow cytometry-acquired data presented in this figure is provided in Supplementary Fig. 4.

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