Fig. 7: T cell responses in NHP vaccinated with Sing16 HA mRNA-LNP vaccine.
From: Development of multivalent mRNA vaccine candidates for seasonal or pandemic influenza
Cynomolgus macaques (n = 6 per group) were injected twice, 4 weeks apart by IM route, with 45, 135, or 250 μg of Sing16 HA mRNA-LNP. T cells were determined by ELISPOT on day 42 in PBMC stimulated in vitro with peptide pools to represent the entire HA open reading frame. The responses of PBMC secreting IFNɣ (a) or IL-13 (b) calculated as spots forming cells (SFC) per million PBMC are shown. Each symbol represents an individual sample, and the bar represents the mean with standard deviation for the group.
