Table 2 IgG depletion with shPro/CM1 protein.

From: Elucidating functional epitopes within the N-terminal region of malaria transmission blocking vaccine antigen Pfs230

IgG name

Antibody levela

Functional activityb

Total IgG

Depleted IgG

Total IgG

Depleted IgG

EU

EU

(%)c

%TRA

(95%CI)

p

%TRA

(95%CI)

p

cPro/CM1-4

14,242

1,189

(8)

95

(90–98)

0.001

58

(27– 77)

0.004

cPro/CM1-3

42,980

288

(1)

100

(99–100)

0.001

72

(53–85)

0.001

cPro/CM1-2

25,974

427

(2)

94

(89–97)

0.001

78

(59–88)

0.001

cPro/CM1

34,334

239

(1)

99

(97–100)

0.001

48

(6–70)

0.032

shPro/CM1

103,414

46,286

(45)

99

(97–100)

0.001

78

(62–88)

0.001

GST

15

N.A.d

N.A.e

−3

(−81–40)

0.909

  1. aAnti-shPro/CM1 ELISA units (EU).
  2. bFunctional activity was measured by SMFA. Percent inhibition in oocyst density (%TRA), the 95% confidence interval (95%CI) and p-value are shown. The original numbers in each assay are shown in Table S4.
  3. cThe proportion (%) of remaining shPro/CM1-specific antibodies in the depleted IgGs.
  4. dToo low to determine.
  5. eAnti-GST total IgG was used as a negative control.
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