Table 1 Characteristics of the four clinical trials that generated transcriptomic data used to identify preimmunization correlates of protection.
From: Preimmunization correlates of protection shared across malaria vaccine trials in adults
IMRAS Immunization via Mosquito Bite with Radiation-Attenuated P. falciparum Sporozoites | BSPZV1 Bagamoyo SPoroZoite Vaccination 1 | MAL68 | CPS Chloroquine Prophylaxis and Sporozoites | |
|---|---|---|---|---|
ClinicalTrials.gov ID | NCT01994525 | NCT02132299 | NCT01366534 | NCT01218893 |
Immunogen | Radiation-attenuated sporozoites via mosquito bite | Radiation-attenuated sporozoites via IV injection | RTS,S/A01 ± Ad35.CS.01 vaccine via injection | Sporozoites via mosquito bite (under chloroquine cover) |
Recruitment country | U.S.A. | Tanzania | U.S.A. | The Netherlands |
Sample source | Whole blood | Whole blood | PBMCs | Whole blood |
N preimmunization samples | 11 | 22 | 45 | 7 |
Prior malaria exposure | Naive | Non-naive | Naive | Naive |
N female/male | 1 / 10 | 0 / 22 | 20 / 25 | 3 / 4 |
N challenge-protected/non-protected | 6 / 5 | 8 / 14 | 21 / 24 | 3 / 4 |
Sequencing system | Illumina HiSeq 2000 | Illumina HiSeq 4000 | Illumina HiSeq 2000 | Illumina NextSeq 500 |
Paired-end or single-read | Paired-end | Paired-end | Paired-end | Paired-end |
