Fig. 4: Correlation between cytokine level and degree of symptoms.

a, b Local and systemic scores were compared with serum IL-6 (a) and TNF-α (b) levels 1 day after the first dose. There were no correlations. c, d Local and systemic scores were compared with serum IL-6 (c) and TNF-α (d) levels 1 day after the second dose. The coefficient of determination (R2) and p-values were calculated (Pearson correlation test, *p < 0.05). Each dot represents a subject.