Fig. 6: Serum extracellular-vesicle miRNA levels.

a EV miRNA levels in sera collected at 1 day before the first dose were determined by RT-qPCR. The heatmap represents the ln (miRNA) values of each miRNA. b–e Local and systemic scores after the first (b, c) and second (d, e) doses were compared with ln (miR) levels. Multiple linear-regression analyses were performed, and multiple coefficients of determination (R2) were calculated. The tables show coefficient (β), standard error (SE), and p-values of each ln (miR). f All subjects were classified into two groups on the basis of the degree of each symptom as indicated. Ln (miR-92a-2-5p) levels in the two groups were compared. Student t-tests were performed (*p < 0.05). The bars represent mean ± SD. Each dot represents a subject.