Fig. 8: Histopathological analysis of naïve or vaccinated mice challenged with SARS-CoV-2. | npj Vaccines

Fig. 8: Histopathological analysis of naïve or vaccinated mice challenged with SARS-CoV-2.

From: Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge

Fig. 8

a 40× magnification of the lung of NVC (scale bar = 300 μm). b 100× magnification of 8A. Inflammation in the parenchyma is denoted by the asterisk, inflammation surrounding the blood vessel is marked by an arrowhead, and inflammation in the airways are denoted by an arrow (scale bar = 125 μm). c 40× magnification of the lung of the IN BReC-CoV-2 vaccinated representative mouse (scale bar = 300 μm). d 100× magnification of 8C. Arrows show inflammation in the airways (scale bar = 125 μm). e 40× magnification of the lung of the IM BReC-CoV-2 vaccinated representative mouse (scale bar = 300μm). f inflammation in the parenchyma is denoted by the asterisk, surrounding the blood vessels marked by an arrowhead and inflammation in the airways represented by arrows (scale bar = 125 μm). g Total chronic inflammation scores of each mouse. h Total acute inflammation score of each mouse. Results represented as mean ± SD. All statistical analysis was performed using Kruskal–Wallis test with Dunn’s multiple comparisons test. P = 0.0449* (chronic); P = 0.0143, 0.150*, 0.0004*** (acute).

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