Fig. 6: Lung pathology in vaccinated and unvaccinated hamsters.
From: Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters
a Representative HE stain (10X magnification, Scale bar = 100 um) in PIDV-V1, PIDV-V5, and control groups at 4 and 8 days post-infection (n = 4 per group). b Representative Masson’s trichrome staining (10X magnification, Scale bar = 100 um). Collagen is indicated by areas stained in blue. c Quantification of fibrosis (collagen staining) presented as mean percentage fibrosis of total lung tissue. Two-way- ANOVA- Dunnett’s multiple comparisons test was performed (Control vs. PIDV-V1 day 4, ****p < 0.0001, Control vs. PIDV-V5 day 4 ****p < 0.0001, Control vs. PIDV-V1 day 8, ****p < 0.0001, Control vs. PIDV-V5 day 8 ****p < 0.0001). Scale bar represents 100 μm.
