Fig. 7: Histopathology of kidneys in vaccinated and unvaccinated hamsters.
From: Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters
a Representative H&E staining (10X magnification, Scale bar = 100 um) in pIDV-V1, pIDV-V5, and control groups at 4, 8 days post-infection (n = 4 per group). b Representative Masson’s trichrome staining (10X magnification, Scale bar = 100 um) in pIDV-V1, pIDV-V5, and control groups at 4, 8 days post-infection (n = 4). Collagen is indicated by areas stained in blue. c Quantification of inflammatory cell infiltration in kidney tissues of control, pIDV-VI, and pIDV-V5 vaccinated groups. Two-way- ANOVA- Dunnett’s multiple comparisons test was performed (Control vs. pIDV-V1 day 4, **p = 0.0011, Control vs. pIDV-V5 day 4 **p = 0.0017, Control vs. pIDV-V1 day 8, ***p = 0.0001, Control vs. pIDV-V5 day 8 ****p = 0.0404). d Quantification of fibrosis (collagen staining) presented as mean percentage fibrosis of total kidney tissue. Two-way- ANOVA- Dunnett’s multiple comparisons test was performed (Control vs. pIDV-V1 day 4, *p = 0.0241, Control vs. pIDV-V5 day 4 **p = 0.0057, Control vs. pIDV-V1 day 8, **p = 0.0077, Control vs. pIDV-V5 day 8 *p = 0.0120). Scale bar represents 100 μm.
