Fig. 6: Immune response in mice immunized with IDLV delivering soluble or membrane-tethered ConSOSL.UFO. | npj Vaccines

Fig. 6: Immune response in mice immunized with IDLV delivering soluble or membrane-tethered ConSOSL.UFO.

From: Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

Fig. 6

a Immunization schedule of BALB/c mice. Five mice/group were vaccinated once with escalating doses (0.4 × 106, 2 × 106, 10 × 106 RT units/mouse) of SIV-based IDLVs expressing either soluble ConSOSL.UFO.664 or membrane-tethered ConSOSL.UFO.750. Sera were collected at the indicated time point. b Time course of anti-ConSOSL.UFO Env IgG measured by ELISA in sera of BALB/c mice (5 mice/group) immunized with either IDLV-UFO.750 (black dots) or IDLV-UFO.664 (empty dots). Samples from immunized mice were analyzed separately. Results are expressed as IgG ng/ml and shown as box and whisker plots. *p < 0.05, **p < 0.01, Mann-Whitney test.

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