Fig. 7: Immune response in cynomolgus macaques after prime-boost vaccination with IDLV-UFO.750 and ConM SOSIP.v7 protein. | npj Vaccines

Fig. 7: Immune response in cynomolgus macaques after prime-boost vaccination with IDLV-UFO.750 and ConM SOSIP.v7 protein.

From: Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

Fig. 7

a Schematic representation of schedule of immunization of five cynomolgus macaques primed with IDLV-UFO.750 pseudotyped with VSV.G from Indiana serotype (In.G) and boosted at week 37 after the first immunization with the same IDLV-UFO.750 but pseudotyped with VSV.G from Cocal serotype (Co.G). At 62 and 74 weeks after priming, monkeys were vaccinated with ConM SOSIP.v7 protein adjuvanted with MPLA. Serum and mucosal samples from vaccinated macaques were collected at the indicated time points (Weeks). b Time course of anti-Env IgG measured by capture ELISA in the sera of the immunized animals. Results are expressed as mean concentration (ng/ml) of specific anti-ConSOSL.UFO (solid line) and anti-ConM (dotted line) IgG. Arrows indicate the immunization. Error bars indicate the standard error of the mean.

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