Table 2 Serum neutralization activity against the clade C tier 1A MW965.26 and the Consensus tier 1B ConS viruses.

From: Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

 

MW965.26 tier 1A

ConS tier 1B

Animal ID

Animal ID

Vaccine Group

Week

AS304

AT777

AU018

AU955

AU989

AS304

AU955

IDLV-UFO.750

0

<20

<20

<20

<20

<20

<20

<20

2

<20

<20

<20

<20

<20

<20

<20

6

<20

<20

<20

29

<20

<20

<20

10

<20

27

<20

104

90

<20

<20

22

47

71

<20

203

378

<20

<20

IDLV-UFO.750

37

58

99

<20

265

853

<20

<20

39

4614

9278

930

35035

8459

<20

<20

43

1164

3076

418

7200

3139

<20

<20

47

552

2428

103

4013

1629

<20

<20

57

274

708

50

1578

1409

<20

<20

ConM SOSIP.v7 + MPLA

62

216

796

44

1159

1659

<20

<20

64

6080

7347

260

43740

7354

24

99

69

971

2547

187

5714

3589

<20

24

ConM SOSIP.v7 + MPLA

74

467

1647

69

1751

2065

<20

<20

76

3618

4281

459

21270

17007

137

198

80

944

1936

309

7507

6515

<20

<20

85

447

1132

211

2413

1915

<20

<20

89

379

817

160

1200

2210

<20

<20

94

329

774

116

931

2917

<20

<20

  1. Values are indicated as the serum dilution at which relative luminescence units (RLUs) were reduced 50% compared to virus control wells after subtraction of background RLUs in cell control wells. A response was considered positive (shown in bold) if the ID50 was three times greater than the signal against the MLV-pseudotyped negative control virus.
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