Fig. 2: pWRG/VEE delivered by IM- or ID-DSJI elicits anti-VEEV neutralizing antibodies. | npj Vaccines

Fig. 2: pWRG/VEE delivered by IM- or ID-DSJI elicits anti-VEEV neutralizing antibodies.

From: A DNA vaccine targeting VEE virus delivered by needle-free jet-injection protects macaques against aerosol challenge

Fig. 2

a Temporal anti-VEEV GP neutralizing antibody responses and (b) PsVNA neutralizing antibody titers in vaccinated nonhuman primates. c PRNT titers 4 weeks post 2nd vaccination. The shaded areas represent the assay limit based on the lowest dilution of serum tested. Arrows represent vaccination time points. Data represent the group geometric mean ± geometric SD. *p < 0.05, **p < 0.01. d Correlation analysis to evaluate the relation of the VEEV PsVNA80 and PRNT80. For panels (a) and (c), p values were determined by one-way ANOVA with Tukey’s multiple comparison test. For panel (b), p values were determined by two-way ANOVA with Tukey’s multiple comparison. For panel (d), linear regression and 95% CI is shown as line and dotted lines, respectively. Circled symbols represent individual animals in VEEV-vaccinated groups that developed a fever >3 °C above baseline after VEEV aerosol challenge.

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