Table 1 Pathology scores of isolated brain sections.

From: A DNA vaccine targeting VEE virus delivered by needle-free jet-injection protects macaques against aerosol challenge

Vaccine

NHP number

Frontal cortex

Corpus striatum

Thalamus

Mesencephalon

Cerebellum

Pons

Medulla oblongata

Meningitis

Total score

Empty vector

2

0

1

1

0

0

0

0

0

2

Empty vector

8

2

2

2

2

0

2

0

1

11

Empty vector

11

1

1

1

0

0

0

0

1

4

Empty vector

13

0

1

1

1

0

0

0

0

3

Empty vector

15

1

1

1

0

0

0

0

1

4

Empty vector

17

1

1

1

0

0

0

0

0

3

Empty vector

Total Score

5

7

7

3

0

2

0

3

27

IM-DSJI

5

1

2

2

0

0

0

0

1

6

IM-DSJI

6

0

0

0

0

0

0

0

0

0

IM-DSJI

9

0

1

1

0

0

0

0

0

2

IM-DSJI

12

0

0

0

0

0

0

0

0

0

IM-DSJI

14

0

0

0

0

0

0

0

0

0

IM-DSJI

18

3

3

3

3

0

3

3

2

20

IM-DSJI

Total Score

4

6

6

3

0

3

3

3

28

ID-DSJI

1

2

2

1

2

0

2

2

2

13

ID-DSJI

3

0

0

0

0

0

0

0

0

0

ID-DSJI

4

0

1

0

0

0

0

0

1

2

ID-DSJI

7

0

0

0

0

0

0

0

0

0

ID-DSJI

10

0

0

0

0

0

0

0

0

0

ID-DSJI

16

0

0

0

0

0

0

0

0

0

ID-DSJI

Total Score

2

3

1

2

0

2

2

2

15

All Animals

Total Score

11

16

14

8

0

7

5

9

70

  1. Pathology score based on percentage of tissue affected by the histologic changes 0-negative, 1-minimal, >0–10%, 2-mild, >10–25%, 3-moderate, >25–50%, and 4-marked, >50–75%.
  2. NHP Nonhuman primate.