Fig. 3: Lung CD4 T cell responses to immunization with RBD-NP and adjuvants. | npj Vaccines

Fig. 3: Lung CD4 T cell responses to immunization with RBD-NP and adjuvants.

From: Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice

Fig. 3

a Representative flow cytometry plots of CD4 T cell cytokine production following stimulation with overlapping peptides from SARS-CoV-2 spike protein at day 7 post-immunization. b Frequency of total cytokine-producing CD4 T cells at day 7 and day 33 post-immunization. Error bars indicate mean ± SEM. c Individual cytokines produced by CD4 T cells in response to overlapping peptide pool at day 7 and day 33 post-immunization. d Pie charts representing the average proportions of cytokine-producing cells positive for either one, two or three cytokines. a–d Results from 2 independent experiments with n = 4 mice per experiment. P-values: * denotes p < 0.0332, **p < 0.0021, ***p < 0.0002, and ****p < 0.0001.

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