Fig. 7: Neutralization activity of the pSARS2-S DNA vaccine against SARS-CoV-2 variants in the repeated-dose toxicity study. | npj Vaccines

Fig. 7: Neutralization activity of the pSARS2-S DNA vaccine against SARS-CoV-2 variants in the repeated-dose toxicity study.

From: A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection

Fig. 7

Male SD rats (n = 5 per group) were intramuscularly immunized three times at a 2-week interval with placebo and 1 mg of pSARS2-S DNA, followed by electrostimulation using an electroacupuncture machine (40 Vpp and 120 Hz for 5 s). Serum samples obtained at week 9 after the first immunization were used to evaluate the neutralizing activity against SARS-CoV-2 variants (Wuhan (WT), Alpha, Beta, Gamma, Delta) using neutralization assay. The dashed line indicates the initial fold dilution of serum samples. The neutralizing geometric mean titers (GMT) and the GMT fold change over WT strain are shown. Neutralization titers are expressed as the geometric mean with a 95% confidence interval.

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