Fig. 2: Gcc-foldon induces greatest breadth of antibody responses. | npj Vaccines

Fig. 2: Gcc-foldon induces greatest breadth of antibody responses.

From: Immunogenicity and protective efficacy of RSV G central conserved domain vaccine with a prefusion nanoparticle

Fig. 2

Groups of five mice were intramuscularly immunized with 0.5 µg/dose of Gcc-NP and molar equivalents of Gcc peptide of the other antigens formulated with the AF0333 squalene-based emulsion adjuvant on days 0, 21, and 42. Blood was collected 14 days after the last immunization. Naive is pooled pre-immune sera. Binding Ab titers were determined by ELISA using plates coated with peptide corresponding to the RSV Gcc of a strain A2 or b strain B1. NAb titers were determined on HAE cells against RSV strains c A2 and d B1. Dotted lines represent limits of detection. Error bars represent 1 geometric standard deviation from the geometric mean. All statistical values were performed using Student’s t-test.

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