Fig. 7: Epigraph immunization induces cross-reactive antibody responses in ferrets against a panel of 18 representative H3 viruses. | npj Vaccines

Fig. 7: Epigraph immunization induces cross-reactive antibody responses in ferrets against a panel of 18 representative H3 viruses.

From: An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

Fig. 7

Ferrets (n = 10) were immunized with 5 × 1010 vp of the HAdV-5-Epigraph vaccine, a full human dose of FluZone, or a mock PBS vaccine. Antibody responses were measured using a HI assay against the 18 H3 representative strains for both a single immunization (a) or after boosting (b). A heat map of these HI titers was constructed to further visualize the total cross-reactive antibody response of each vaccine. Data are presented as the mean with standard error (SEM) (n = 10; unpaired T test).

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