Fig. 7: Multiple antibody functions are associated with a module of specific antibody features.

A, B Feature correlation networks. Edges (green lines for positive correlation, red lines for negative correlation) between nodes depict relationships with Pearson correlation coefficients (R_P) < 0.3. A A weighted correlation network of antibody response feature modules was identified by hierarchical clustering and dynamic tree cutting. Features are colored by module and graphed according to degree and direction of correlation (R_P). B Correlation network for features found within each module. Nodes (features) are colored by Fc characteristic. C Heatmap depicting correlative relationships between antibody functions (columns) and feature module eigenvalues (rows). Pearson correlation coefficients (R_P) and p-values are shown in inset. 2AH indicates binding to FcγRIIAH, 2B indicates binding to FcγRIIB, 3AF indicates binding to FcγRIIIAF, and 3BNA2 indicates binding to FcγRIIIBNA2.