Table 2 SF-2 gp120 Binding antibody response summary.
Day 0 | Day 182 | Day 364 | Day 532 | |
|---|---|---|---|---|
IgG | ||||
C: Placebo | 116 (114, 118) | 141 (139, 170) | 124 (111, 137) | 106 (95, 119) |
T1: Alum | 110 (103, 115) | 6618 (4302, 17518) | 1126 (319, 2459) | 573 (262, 1770) |
T2: Liposomal MPL | 106 (100, 112) | 766 (514, 4551) | 404 (192, 988) | 247 (162, 490) |
T4: MF59 | 100 (98, 114) | 8274 (3319, 21896) | 2369 (1417, 3031) | 1855 (1045, 2657) |
T5: MF59 + MTP-PE | 108 (104, 120) | 27247 (22087, 49264) | 5770 (2732, 9170) | 4575 (1854, 7715) |
T6: SAF/2 | 93 (92, 104) | 52246 (27353, 61270) | 11504 (9118, 20394) | 9286 (6851, 13089) |
T7: SAF/2 + MDP | 117 (102, 122) | 54494 (35462, 69781) | 9532 (6708, 17217) | 7528 (5383, 12553) |
IgA | ||||
C: Placebo | 50 (43, 1455) | 62 (39, 1496) | 60 (39, 1337) | 54 (39, 1423) |
T1: Alum | 78 (45, 494) | 440 (206, 4510) | 357 (82, 1504) | 258 (77, 698) |
T2: Liposomal MPL | 92 (72, 324) | 197 (92, 467) | 94 (86, 179) | 101 (79, 524) |
T4: MF59 | 74 (63, 128) | 616 (246, 1809) | 190 (136, 399) | 150 (104, 274) |
T5: MF59 + MTP-PE | 179 (85, 568) | 1737 (803, 7551) | 704 (289, 2462) | 839 (306, 2986) |
T6: SAF/2 | 118 (30, 176) | 4133 (2557, 7674) | 574 (287, 612) | 468 (229, 906) |
T7: SAF/2 + MDP | 140 (109, 270) | 1958 (1292, 21030) | 609 (432, 1858) | 496 (292, 1658) |
IgG2 | ||||
C: Placebo | 6 (3, 16) | 12 (3, 25) | 5 (3, 28) | 6 (3, 24) |
T1: Alum | 6 (6, 12) | 10 (6, 62) | 5 (4, 9) | 8 (3, 16) |
T2: Liposomal MPL | 5 (4, 6) | 6 (6, 14) | 6 (4, 8) | 7 (4, 11) |
T4: MF59 | 4 (1, 6) | 6 (4, 6) | 4 (2, 5) | 4 (4, 4) |
T5: MF59 + MTP-PE | 5 (2, 33) | 26 (10, 51) | 12 (4, 20) | 9 (4, 16) |
T6: SAF/2 | 5 (2, 11) | 22 (10, 38) | 12 (7, 32) | 10 (6, 23) |
T7: SAF/2 + MDP | 6 (4, 12) | 19 (8, 25) | 10 (8, 15) | 9 (4, 12) |
IgG3 | ||||
C: Placebo | 2 (1, 2) | 2 (1, 2) | 2 (1, 2) | 2 (1, 3) |
T1: Alum | 1 (1, 3) | 16 (4, 27) | 2 (1, 4) | 2 (1, 3) |
T2: Liposomal MPL | 2 (2, 4) | 8 (3, 42) | 4 (1, 8) | 4 (1, 10) |
T4: MF59 | 1 (1, 1) | 10 (4, 100) | 2 (1, 3) | 2 (1, 3) |
T5: MF59 + MTP-PE | 1 (1, 2) | 42 (24, 124) | 5 (1, 13) | 2 (1, 8) |
T6: SAF/2 | 1 (1, 2) | 166 (37, 2056) | 26 (8, 66) | 14 (7, 45) |
T7: SAF/2 + MDP | 1 (1, 2) | 88 (44, 191) | 10 (5, 53) | 8 (3, 39) |
2AH | ||||
C: Placebo | 113 (111, 114) | 147 (131, 158) | 131 (123, 140) | 122 (107, 134) |
T1: Alum | 122 (110, 136) | 7726 (3466, 43445) | 182 (141, 248) | 150 (117, 224) |
T2: Liposomal MPL | 141 (121, 158) | 153 (117, 1707) | 123 (113, 146) | 126 (116, 152) |
T4: MF59 | 122 (112, 133) | 21434 (1420, 50664) | 250 (170, 498) | 279 (152, 470) |
T5: MF59 + MTP-PE | 121 (101, 164) | 54926 (39344, 98460) | 3587 (298, 6840) | 2638 (272, 9102) |
T6: SAF/2 | 109 (106, 110) | 97338 (66302, 108843) | 12354 (8101, 35026) | 13982 (8377, 20958) |
T7: SAF/2 + MDP | 126 (117, 143) | 106868 (72747, 121201) | 8345 (3286, 28480) | 7881 (1844, 34080) |
3AF | ||||
C: Placebo | 115 (106, 124) | 106 (103, 108) | 109 (104, 112) | 114 (102, 128) |
T1: Alum | 104 (98, 111) | 1234 (841, 9957) | 105 (98, 116) | 116 (104, 126) |
T2: Liposomal MPL | 117 (110, 122) | 108 (100, 280) | 98 (90, 109) | 112 (97, 114) |
T4: MF59 | 107 (97, 116) | 13195 (499, 37570) | 123 (102, 178) | 118 (110, 164) |
T5: MF59 + MTP-PE | 107 (100, 115) | 46103 (11138, 67220) | 455 (114, 1452) | 483 (137, 1089) |
T6: SAF/2 | 107 (105, 107) | 56160 (44682, 83931) | 3150 (825, 13164) | 1851 (1478, 10220) |
T7: SAF/2 + MDP | 108 (94, 118) | 71527 (62141, 89254) | 1511 (488, 8908) | 2654 (560, 12915) |
