Table 1 Recombinant MeV-derived vaccines targeting diseases transmitted via the respiratory pathway.
From: Versatility of live-attenuated measles viruses as platform technology for recombinant vaccines
Target | Antigen | ATUa | Strainb | IFNAR−/−c | CD46-miced | Cotton rats | Syr. Hamsterse | Rhesus mac. | Cynomolgus | AGMf | HI Absg | ELISAh | nAbsi | ELISpotj | ICSk | CTLsl | Challengem | Clinical trial | Refs. |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IAV | HA | P | Edm-Zagreb | ||||||||||||||||
HA | P | AIK-C | X | X | X | ||||||||||||||
HA (H5) | N | Edm-B, HLatt | X | X | X | ||||||||||||||
LASV | NP + GPC Z + GPC | P pre-N + P | Schwarz | X | X | Xn | X | X | I | ||||||||||
MERS-CoV | S | P, H | Moraten | X | X | X | X | X | X | ||||||||||
S; N | H; P | Moraten | X | X | X | X | |||||||||||||
MuV | HN, F | P | Edm-B | ||||||||||||||||
HN | P | Edm-Zagreb | |||||||||||||||||
NiV | G | N | Edm-B, wtHL | X | X | X | X | ||||||||||||
RSV | F | pre-N, P | Edm-Zagreb | X | X | X | X | X | X | ||||||||||
G, F | P | AIK-C | X | X | X | X | |||||||||||||
G, F | Chimerao | AIK-C | X | X | X | ||||||||||||||
F, M2-1, NP | P | AIK-C | X | X | X | X | |||||||||||||
SARS-CoV | S, N | P | Edm-Zagreb | X | X | X | X | ||||||||||||
S | P | Schwarz | X | X | X | X | |||||||||||||
SARS-CoV-2 | S | H | Moraten | X | X | X | X | X | X | X | X | I/ II | |||||||
S | P | Schwarz | X | X | X | X | X | X | X | X | X | ||||||||
S | P | Schwarz | X | X | X | X | X | X | X | ||||||||||
S | Pp | Schwarz | X | X | negq |