Table 2 Recombinant MeV vaccines targeting arthropod-borne diseases.
From: Versatility of live-attenuated measles viruses as platform technology for recombinant vaccines
Target | Antigen | ATUa | Strainb | CD46-micec | BL/6-hCD46d | AG-hCD46e | Cotton rats | SMf | Cynomolgus | ELISAg | nAbsh | ELISpoti | ICSj | Challengek | Clinical trial | Reference |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHIKV | C-E3-E2-6K-E1 | P | Schwarz | X | X | X | X | X | X | II | ||||||
DENV | EDIII, EDIII-ectoM, Tetra-EDIII-ectoM | P | Schwarz | X | X | X | Xl | |||||||||
Tandem-EDIII | P | Moraten | X | X | X | X | X | |||||||||
EDIII-HBsAg | N, P | Moraten | X | X | ||||||||||||
JEV | prM-E | P | AIK-C | X | X | X | ||||||||||
Plasmodium falciparum; P. berghei m (malaria) | CS (Pb or Pf) | P | Schwarz | X | X | X | X | X | ||||||||
WNV | E | P | Schwarz | X | X | X | X | X | ||||||||
ZIKV | E | P | Schwarz | X | X | X | X | X | I | |||||||
prME, NS1,prME-NS1 | pre-N, N N N, H | Edm-B | X | X X X | X X | X X |