Table 4 Recombinant MeV vaccines targeting diseases transmitted by fluids or sexual contact.
From: Versatility of live-attenuated measles viruses as platform technology for recombinant vaccines
Target | Antigen | ATUa | Strainb | IFNAR−/− c | CD46-miced | hum. Micee | Cotton rats | Rhesus mac. | Cynomolgus | ELISAf | nAbsg | ELISpoth | ICSi | Challengej | Clinical trial | Refs. |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EBV | gB350 | N, P | Edm-Zagreb | X | X | X | neg | X | ||||||||
HBV | HBsAg | P | Edm-B | X | X | |||||||||||
HBsAg | N, P, H, L | Moraten | X | X | X | MeV | ||||||||||
HCV | E1, E2 | N | Edm-B | X | X | |||||||||||
C, E1, E2; E1/Ft, E2/Ft | P | Moraten | X | X | X | |||||||||||
Helicobacter pylori | NAP | pre-N | Edm-B | X | X | X | X | |||||||||
HIV-1 | Env | P, H | Edm-B | X | X | X | X | X | X | I | ||||||
Env | P | Schwarz | X | X | X | X | ||||||||||
Gag + Env | P H | Schwarz | X | X | X | X | ||||||||||
Env, Gag + Pol; Gag | P P, H; P | Moraten | X | X | X | |||||||||||
F4 | P | Schwarz | X | X | X | X | ||||||||||
HPV | L1 | P | Edm-Zagreb | X | X | X | X | |||||||||
SHIV | Gag, Env; Nef | P, H; pre-N | Schwarz | X | X | X | X | X | X | |||||||
SIVmac | Env; Pol; Gag | P, H; P; H | Edm-B | |||||||||||||
Env (+ Pol); Gag | P; H | Edm-B | X | X | ||||||||||||
Gag | P | Edm-Zagreb | X | X | X | X |