Fig. 5: Enumeration and comparison of circulating SARS-CoV-2 S- and N-specific T cells following infection, primary vaccination and secondary vaccination. | npj Vaccines

Fig. 5: Enumeration and comparison of circulating SARS-CoV-2 S- and N-specific T cells following infection, primary vaccination and secondary vaccination.

From: Moderate to severe SARS-CoV-2 infection primes vaccine-induced immunity more effectively than asymptomatic or mild infection

Fig. 5

After 24 h stimulation with S or N peptides, antigen-specific circulating T cells were detected as IFN-γ spot forming cells (SFC). Results from sequential samples obtained after infection, PV1 and PV2 were expressed as SFC/million PBMC and shown for a asymptomatic/mild (n = 8) and b moderate/severe (n = 11) groups. P values in a and b were calculated using Friedman’s test with Dunn’s multiple comparisons test and significance is shown above lines spanning the groups compared. Comparisons of IFN-γ SFC/million PBMC after S stimulation between the two groups are shown c after infection, d PV1, and e PV2. Comparisons of N-specific IFN-γ SFC/million PBMC are depicted for samples taken f after infection, g PV1 and h PV2. P values in c–h were calculated using the Mann–Whitney U-test. Red lines bisecting groups represent median (solid) with IQR (dotted).

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