Table 2 Gametocyte, oocyst, and sporozoite production of four P. falciparum gene-deletion mutants and wild-type WT PfNF54.
Lines | Stage V Gam. (%)1 | Exflag./105 RBC2 | Infection rate (%)3 | Oocyst no.4 | Spor. no (×103)6 |
|---|---|---|---|---|---|
Average (s.d) | Average (s.d.) | Average (s.d.) | Average (s.d.) | Average (s.d.) | |
WT PfNF54 | 2.04 (0.88) | 804 (387) | 66 (39) | 92 (86) | 53 (51) |
0.8–3.7 (11 exp.) | 201–1459 (27 exp.) | 68–100 (34 exp.) | 21–247 (34 exp.) | 4–155 (34 exp.) | |
PfΔpalm | 2.85 (1.34) | 1544 (116) | 75 (18) | 38 (27) | 0 |
1.9–3.8 (2 exp.) | 1462–1626 (2 exp.) | 56–93 (4 exp.) | 19–64 (4 exp.) | (4 exp.) | |
PfΔcbr | 1.6 (0.6) | 440 (219) | 53 (45) | 65 (52) | 0 |
0.8–2.1 (4 exp.) | 147–660 (9 exp.) | 54–100 (13 exp.) | 22–156 (13 exp.) | (11 exp.) | |
PfΔhcs1 | 2.6 (0.8) | 459 (133) | 92(14) | 89 (42) | 0 |
1.8–3.3 (3 exp.) | 365–554 (2 exp.) | 76–100 (3 exp.) | 63–138 (3 exp.) | (3 exp.) | |
PfΔmei2 | 2.1 (0.6) | 288 (182) | 73 (32) | 63 (68) | 31 (26) |
1.8–2.8 (3 exp.) | 94–600 (9 exp.) | 23–100 (14 exp.) | 14–167 (13 exp.) | 10–84 (9 exp.) |
