Fig. 10: Multivalent VSV virion vaccination prevented the development of histologic lesions in hamsters challenged with Nipah, Hendra, or Ebola viruses. | npj Vaccines

Fig. 10: Multivalent VSV virion vaccination prevented the development of histologic lesions in hamsters challenged with Nipah, Hendra, or Ebola viruses.

From: Multivalent viral particles elicit safe and efficient immunoprotection against Nipah Hendra and Ebola viruses

Fig. 10

Tissues from representative mock vaccinated (A, C, E, G) or multivalent VSV virion vaccination (B, D, F, H) following challenge with either Nipah (A–D) or Ebola virus (E–H). A Brain tissue from a representative mock vaccinated hamster with inflammatory perivascular cuffs (arrows). C Lung tissue from a representative mock vaccinated hamster with intravascular fibrin thrombi (arrowhead), edema in alveoli (asterisk), and type II pneumocyte hyperplasia with atypia (arrow). E Liver tissue from a from a representative mock vaccinated hamster with lobular hepatitis, hepatocyte necrosis (arrow), and intracytoplasmic viral inclusions (arrowhead). G Lung tissue from a representative mock vaccinated hamster with intravascular fibrinocellular debris (arrows) and expansion of alveolar septa with inflammatory cells (arrowhead). Lesions caused by Hendra virus resembled those caused by Nipah virus. H&E, scale bar = 50 μm.

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