Table 1 ΔM27-MCMV stimulates cytokine responses.
From: Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
Cytokine | naive mean ± SD | wt 3 dpi mean ± SD | ΔM27 3 dpi mean ± SD | ΔM27 vs Mock 3 dpi p value | ΔM27 vs wt 3 dpi p value | wt 21 dpi mean ± SD | ΔM27 21 dpi mean ± SD | ΔM27 vs Mock 21 dpi p value | ΔM27 vs wt 21 dpi p value |
|---|---|---|---|---|---|---|---|---|---|
TNFα | 0.59 ± 0.44 | 4.29 ± 3.96 | 2.85 ± 0.47 | 0.0004 | NS | 0.54 ± 0.11 | 0.81 ± 0.13 | NS | 0.02 |
IL-6 | 2.89 ± 1.39 | 47.64 ± 55.89 | 14.11 ± 2.01 | 0.0002 | NS | 2.19 ± 0 | 1.82 ± 0.9 | NS | NS |
CXCL10/IP-10 | 19.39 ± 8.51 | 778.54 ± 743.95 | 384.84 ± 43.22 | 0.0003 | NS | 18.72 ± 3.82 | 20.24 ± 6.11 | NS | NS |
CCL5/RANTES | 137.95 ± 102.59 | 414.73 ± 432.59 | 380.19 ± 65.45 | 0.0101 | NS | 64.26 ± 15.78 | 96.53 ± 32.93 | NS | NS |
CCL4/MIP-1β | 6.20 ± 0 | 334.18 ± 267.75 | 217.63 ± 36.61 | 0.0014 | NS | 6.20 ± 0 | 6.20 ± 0 | ND | ND |
CXCL1 | 116.60 ± 158.67 | 224.56 ± 218.38 | 171.86 ± 78.98 | NS | NS | 26.84 ± 6.26 | 42.61 ± 17.59 | NS | NS |
IL-12p70 | 5.81 ± 6.36 | 20.17 ± 18.34 | 10.22 ± 0 | NS | NS | 2.07 ± 0.65 | 2.96 ± 0.66 | NS | NS |
IL-1β | 11.07 ± 4.14 | 10.26 ± 1.45 | 9.63 ± 1.26 | NS | NS | 9.63 ± 1.26 | 11.70 ± 3.91 | NS | NS |
IL-33 | 44.09 ± 30.45 | 26.15 ± 29.44 | 23.81 ± 14.80 | NS | NS | 34.42 ± 23.29 | 54.59 ± 19.99 | NS | NS |
