Fig. 5: Systemic and localised presence of IL-17A. | npj Vaccines

Fig. 5: Systemic and localised presence of IL-17A.

From: Streptococcus pyogenes vaccine candidates do not induce autoimmune responses in a rheumatic heart disease model

Fig. 5

Detection of pro-inflammatory IL-17A in the sera and cardiac tissues of rats injected with PBS, rM5, P*17-DT or K4S2-DT. IL-17A in sera was assessed by ELISA (a). Absorbance values at day-35 are shown. Statistical analysis performed by one-way ANOVA with multiple comparison test. Significance to PBS control group, *P < 0.05 and ****P < 0.0001. Error bars represent standard deviation. Tissue-specific localisation of IL-17A in the myocardium and valvular tissues of rats was investigated by immunohistochemical staining (b). Representative images from two rats in each group given (b, S1). Images magnified at ×200, snippets magnified at ×400, and scale bar represents 50 µm.

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