Fig. 2: Humoral immune response of BLAB/c mice activated by the immunization with mRNA-PcrV and mRNA-OprF-I vaccines. | npj Vaccines

Fig. 2: Humoral immune response of BLAB/c mice activated by the immunization with mRNA-PcrV and mRNA-OprF-I vaccines.

From: Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

Fig. 2

a Timeline of mice immunization, blood collection and PA challenging. b The IgM levels induced by mRNA vaccines seven days after the first immunization with different doses of mRNA-PcrV-LNP and mRNA-OprF-I-LNP. c Specific IgG titers in mice sera seven days after the first immunization with mRNA-PcrV-LNP. d Specific IgG titers in mice sera seven days after the first immunization with mRNA-OprF-I-LNP. e Specific IgG titers in mice sera seven days after the second immunization with mRNA-PcrV-LNP. f Specific IgG titers in mice sera seven days after the second immunization with mRNA-OprF-I-LNP. g IgM, IgG1, and IgG2a titers in mRNA-PcrV-LNP immunized mice sera. h IgM, IgG1, and IgG2a titers in mRNA-OprF-I-LNP immunized mice sera. Mice in each group n = 8. One-way ANOVA was performed (ns non-significance, *P < 0.05, **P < 0.01, ***P < 0.001). Data are presented as means ± SEM.

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