Fig. 6: Protective effect of mRNA-PcrV-LNP and mRNA-OprF-I-LNP vaccines in mice. | npj Vaccines

Fig. 6: Protective effect of mRNA-PcrV-LNP and mRNA-OprF-I-LNP vaccines in mice.

From: Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

Fig. 6

a The survival rate of mice protected by mRNA-PcrV-LNP and mRNA-PcrV-LNP vaccines after a challenging with 10xLD50 PAO1 strain in a burn model. b The survival rate of mice protected by mRNA-PcrV-LNP and mRNA-PcrV-LNP vaccines after a challenging with 10xLD50 PA257 strain in a burn model. c The survival rate of mice protected by mRNA-PcrV-LNP and mRNA-PcrV-LNP vaccines after a challenging with 50xLD50 PAO1 strains in a burn model. d The survival rate of mice protected by mRNA-PcrV-LNP and mRNA-PcrV-LNP vaccines after a challenging with 10xLD50 PAO1 strain in a systemic infection model. e The survival rate of mice protected by mRNA-PcrV-LNP and mRNA-PcrV-LNP vaccines after a challenging with 10xLD50 PA16 strain in a systemic infection model. f The survival rate of mice protected by mRNA-PcrV-LNP and mRNA-PcrV-LNP vaccines after a challenging with 10xLD50 PA117 strain in a systemic infection model. Mice in each group n = 8. Data are presented as means ± SEM. The data for survival test were analyzed by Wilcoxon log-rank survival test (ns non-significance, *P < 0.05, **P < 0.01, ***P < 0.001).

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