Fig. 3: Transcriptome analysis for four different vaccination strategies 7 days after boosting.
From: Analyzing immune responses to varied mRNA and protein vaccine sequences
a–d Principal component analysis plot of data obtained for a all samples used in this study, b two homologous vaccination strategies, c two heterologous vaccination strategies, and d four groups with different vaccination strategies. e–h Network of enriched GO immune pathways and genes in e homologous protein-HA immunized (P-P) group, f protein-HA/mRNA-HA immunized (P-R) group, g mRNA-HA/protein-HA immunized (R-P) group, and h homologous mRNA-HA immunized (R-R) group. i Box plot for the expression level of two key DEG (Bcl6, Hmgb1) only significantly upregulated in the mRNA-primed group. j Hmgb1-related enriched GO immune pathway terms upregulated in the R-P group (mRNA-primed group) compared to the P-R group (protein-primed group). Data are represented as the mean ± SD. Statistical significance was analyzed using one-way ANOVA. The significance of the differences between groups is indicated on the bars; *P < 0.05.
