Fig. 2: Serotype-specific OAg IgG and SBA titers against each serotype in the vaccine induced by altSonflex1-2-3 in mice or rabbits compared to corresponding mono-component formulations.
From: A next-generation GMMA-based vaccine candidate to fight shigellosis
a Anti-OAg IgG in mice; b SBA titers in mice; c anti-OAg IgG in rabbits; d SBA titers in rabbits. CD1 mice were immunized IP with 9 ng each OAg per dose; rabbits were immunized IM with 1.5 μg each OAg per dose. Immunizations were performed on days 0 and 28, and sera were analyzed on day 42. Geometric mean (bar) is reported for all groups together with individual values (dots). Statistically significant differences by Mann–Whitney two-tailed test are indicated (* if p < 0.05, ** if p < 0.01).
