Table 1 Serum bactericidal activity against OAg-positive S. sonnei strain for sera depleted and non-depleted of LPS specific antibodies, in participants vaccinated with 1790GAHB (per protocol immunogenicity set)

From: Putative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine

 

Depleted sera

Non-depleted sera33

N

GMT (95% CI)

N

GMT (95% CI)

Day 1

34

16.50 (16.50–16.50)

32

81.95 (57.27–117.26)

Day 29

34

16.50 (16.50–16.50)

32

204.65 (113.56–368.80)

Day 57

34

16.50 (16.50–16.50)

32

171.11 (99.57–294.04)

  1. The lower limit of quantification (LLOQ) for the assay used to assess S. sonnei bactericidal titers after LPS-specific antibodies depletion was an inhibition concentration 50 (IC50) of 33. Titers below the LLOQ were set to half that limit for the purpose of the analysis.
  2. OAg O antigen, LPS lipopolysaccharide, N number of participants, GMT geometric mean titer, CI confidence interval.
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