Fig. 4: Negative correlation between WT and mutant SP/RBD IgG titers at day 0 vs. the fold-change in titer at day 28. | npj Vaccines

Fig. 4: Negative correlation between WT and mutant SP/RBD IgG titers at day 0 vs. the fold-change in titer at day 28.

From: Immunogenicity phase II study evaluating booster capacity of nonadjuvanted AKS-452 SARS-Cov-2 RBD Fc vaccine

Fig. 4

Serum samples were obtained from 67 subjects on days 0 and 28 after receiving the AKS-452 booster dose (90 µg, s.c.) and assessed for IgG binding titers against different mutant SP/RBD antigens via ELISA (x axis) vs. the fold-change in titer per subject at day 28 (y axis). The dotted lines delineate no response (i.e., y = 0) and a 2-fold response (y = 0.3), respectively. For each variant, a bivariate normal distribution fit to X and Y variables was conducted with Log10(day-0 titers) vs. Log10(day-28/day-0 Ratios), respectively. Correlations within each variant data set were significantly different from 0 (p < 0.0001) with a range of correlation coefficients of −0.599 to −0.647.

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