Fig. 5: Protective efficacy of NDV-PFS vaccination against SARS-CoV-2 variants of concern in mice.

K18 mice were vaccinated with NDV-PFS and challenged 28 days following their final dose with either Delta in (a–d) or Omicron (BA.2) in (e–g). a Survival of K18 mice following Delta challenge. b Weight loss in Delta-challenged hamsters. c Maximum weight loss in each of the individual hamsters challenged with Delta that were monitored throughout the course of the experiment. d TCID50 titers in the tissues of each Delta-infected animal euthanized on day 3 post-infection. e Weight loss in BA.2 challenged hamsters. f Maximum weight loss in each of the individual hamsters challenged with BA.2 that were monitored throughout the course of the experiment. g TCID50 titers in the tissues of each BA.2 infected animals euthanized on days 3 or 5 post-infection. In c, d, and g, significance was assessed by one-way ANOVA with multiple comparisons. Exact p values are shown where significant differences are seen. n = 5 or 6 in (a). n = 10 in (b) until day 3, and then n = 6. n = 5 or 6 in (c). n = 4 in (d). n = 10 in (e) until day 5, and n = 5 until day 5. n = 10 in (f). n = 5 per time point in (g). Shown are means + SEM in (b) and (e) and medians in (c), (d), (f), and (g).