Fig. 7: NDV-PFS-mediated protection of Syrian hamsters 168 days following vaccination.

Syrian hamsters were vaccinated with NDV-PFS and challenged with either Delta in b and c or BA.2 in (d) and (e). a WT SARS-CoV-2 spike protein-specific serum IgG endpoint titers following vaccination. Endpoint titers at day 160 are shown along with the same data that is included in Fig. 2a. b Weight loss in Delta-challenged hamsters 168 days post-vaccination. c TCID50 titers in the tissues of each Delta-infected animal euthanized on day 5 post-infection. d Weight loss in BA.2 challenged hamsters. e TCID50 titers in the tissues of each BA.2 infected animals were euthanized on day 5 post-infection. In (c), significance was assessed by the Mann–Whitney test. Exact p values are shown where significant differences are seen. n = 18 at day 160 post-vaccination in (a). n = 9 or 10 in (b) and (d) until day 5, and then n = 4. n = 5 or 6 in (c) and (e). Shown are means in (a), mean + SEM in (b) and (d), and medians in (c) and (e).