Fig. 5: Humoral immune response to vaccination. | npj Vaccines

Fig. 5: Humoral immune response to vaccination.

From: Immunogenicity of 2 therapeutic mosaic HIV-1 vaccine strategies in individuals with HIV-1 on antiretroviral therapy

Fig. 5

A Binding antibodies: Total IgG gp140 ELISA response rates are shown for each group at baseline, and 4 weeks after the second, third and fourth vaccinations at week 12, 24, and 36 respectively. Responders were defined as (1) if baseline<threshold or missing, R>threshold (2) if baseline ≥threshold, R = 3-fold increase from baseline. B Neutralizing antibodies: titers assessed by TZM-bl assay using non-vaccine-matched subtype C pseudovirus (MW965.26). Responders were defined as magnitudes above threshold. C Clade C gp140-specific antibody-dependent cellular phagocytic score. The dotted lines in A and B are the lower and upper limits of assay quantification thresholds. The horizontal lines represent the median response titer. LLOQ lower limit of quantification, ULOQ upper limit of quantification, GMT geometric mean titer.

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